NucPred on Proteomes

Authors: Andrea Krings, Amine Heddad, Markus Brameier and Bob MacCallum, Stockholm Bioinformatics Center, Stockholm University, Sweden.

NucPred - predictions for eukaryotic proteomes

Species:

Note: All filters/tests are combined with AND unless otherwise stated

Show only the proteins with links to database(s):
OMIM - human disease genes
PDB - protein 3D structure
( AND OR combination )

Annotation filters (can be slow! - Perl regexps allowed: e.g. nucleus|nucleolus)

UniProt ID (e.g. "PK3B_")
UniProt description (e.g. "kinase")
UniProt subcellular location
AND
UniProt GO component
AND
AND the
AND the

Only show proteins where the PredictNLS prediction is:

positive
negative

Only show proteins where the PSORT II predicted location

is is not

Click here: to filter by NucPred score

exclude all transmembrane proteins predicted by TMHMM
don't exclude lone N-terminal predicted transmembrane helices
(these could be signal peptides)

export all ACs and IDs as text file

Show proteins (ordered by NucPred score ) from to (currently 98716 matches)

You can bookmark/save your search criteria with this link. You can also start again with default settings.

UniProt accession	UniProt ID	UniProt description	NucPred score	Predict- NLS	PSORT II	TMHMM #helices	UniProt annotation for subcellular location	Uniprot GO cellular component	OMIM	PDB	sequence length
Q8NGR9 UniProt NPD GO	OR1N2_HUMAN	Olfactory receptor 1N2	0.01	-	end	7 *	Membrane; multi-pass membrane protein				316
P23270 UniProt NPD GO	OL226_RAT	Olfactory receptor 226 (Olfactory receptor-like protein I7)	0.01	-	end	7 *	Membrane; multi-pass membrane protein				327
O76000 UniProt NPD GO	OR2B3_HUMAN	Olfactory receptor 2B3 (Olfactory receptor 6-4) (OR6-4) (Olfactory receptor OR6-14) (Hs6M1-1)	0.01	-	end	7 *	Membrane; multi-pass membrane protein				313
Q9GZK6 UniProt NPD GO	OR2J1_HUMAN	Olfactory receptor 2J1 (Olfactory receptor 6-5) (OR6-5) (Hs6M1-4)	0.01	-	end	7 *	Membrane; multi-pass membrane protein				312
O76002 UniProt NPD GO	OR2J2_HUMAN	Olfactory receptor 2J2 (Olfactory receptor 6-8) (OR6-8) (Hs6M1-6)	0.01	-	end	7 *	Membrane; multi-pass membrane protein				312
O76001 UniProt NPD GO	OR2J3_HUMAN	Olfactory receptor 2J3 (Olfactory receptor 6-6) (OR6-6) (Hs6M1-3)	0.01	-	end	7 *	Membrane; multi-pass membrane protein				311
Q96R28 UniProt NPD GO	OR2M2_HUMAN	Olfactory receptor 2M2 (OST423)	0.01	-	end	8 *	Membrane; multi-pass membrane protein				347
Q96R30 UniProt NPD GO	OR2V2_HUMAN	Olfactory receptor 2V2 (Olfactory receptor OR5-3)	0.01	-	end	7 *	Membrane; multi-pass membrane protein				315
Q9TU88 UniProt NPD GO	OR3A2_GORGO	Olfactory receptor 3A2	0.01	-	end	7 *	Membrane; multi-pass membrane protein				315
Q9TU97 UniProt NPD GO	OR3A2_PANTR	Olfactory receptor 3A2	0.01	-	end	6 *	Membrane; multi-pass membrane protein				315
Q6IF82 UniProt NPD GO	O4A47_HUMAN	Olfactory receptor 4A47 (Olfactory receptor OR11-113)	0.01	-	end	8 *	Membrane; multi-pass membrane protein				309
Q8NH72 UniProt NPD GO	OR4C6_HUMAN	Olfactory receptor 4C6 (Olfactory receptor OR11-138)	0.01	-	end	6 *	Membrane; multi-pass membrane protein				309
Q8NGA8 UniProt NPD GO	O4F17_HUMAN	Olfactory receptor 4F17	0.01	-	end	7 *	Membrane; multi-pass membrane protein				305
Q96R69 UniProt NPD GO	OR4F4_HUMAN	Olfactory receptor 4F4 (HS14a-1-A) (Olfactory receptor OR19-3)	0.01	-	end	7 *	Membrane; multi-pass membrane protein				305
Q8NGD2 UniProt NPD GO	OR4K2_HUMAN	Olfactory receptor 4K2	0.01	-	end	7 *	Membrane; multi-pass membrane protein				314
Q8NGD1 UniProt NPD GO	OR4N2_HUMAN	Olfactory receptor 4N2 (Olfactory receptor OR14-8)	0.01	-	end	7 *	Membrane; multi-pass membrane protein				307
Q8NH05 UniProt NPD GO	OR4Q3_HUMAN	Olfactory receptor 4Q3 (Olfactory receptor OR14-3)	0.01	-	end	7 *	Membrane; multi-pass membrane protein				313
Q8NGF9 UniProt NPD GO	OR4X2_HUMAN	Olfactory receptor 4X2	0.01	-	end	8 *	Membrane; multi-pass membrane protein				303
O88628 UniProt NPD GO	O51E2_RAT	Olfactory receptor 51E2 (Olfactory receptor 59) (G-protein coupled receptor RA1c)	0.01	-	vac	7 *	Membrane; multi-pass membrane protein				320
Q9H255 UniProt NPD GO	O51E2_HUMAN	Olfactory receptor 51E2 (Prostate-specific G-protein coupled receptor) (HPRAJ)	0.01	-	end	7 *	Membrane; multi-pass membrane protein	integral to membrane [NAS]			320
Q8NGJ5 UniProt NPD GO	O51L1_HUMAN	Olfactory receptor 51L1	0.01	-	end	7 *	Membrane; multi-pass membrane protein				315
Q9H341 UniProt NPD GO	O51M1_HUMAN	Olfactory receptor 51M1 (Odorant receptor HOR5'beta7) (Olfactory receptor OR11-40)	0.01	-	end	7 *	Membrane; multi-pass membrane protein	integral to membrane [NAS]			315
Q9UKL2 UniProt NPD GO	O52A1_HUMAN	Olfactory receptor 52A1 (HPFH1OR) (Odorant receptor HOR3'beta4)	0.01	-	end	7 *	Membrane; multi-pass membrane protein	integral to plasma membrane [TAS]			312
Q96RD2 UniProt NPD GO	O52B2_HUMAN	Olfactory receptor 52B2	0.01	-	end	7 *	Membrane; multi-pass membrane protein				317
Q8NGJ4 UniProt NPD GO	O52E2_HUMAN	Olfactory receptor 52E2	0.01	-	end	7 *	Membrane; multi-pass membrane protein				325
Q8NGH9 UniProt NPD GO	O52E4_HUMAN	Olfactory receptor 52E4	0.01	-	end	7 *	Membrane; multi-pass membrane protein				312
Q8NGJ2 UniProt NPD GO	O52H1_HUMAN	Olfactory receptor 52H1	0.01	-	end	6 *	Membrane; multi-pass membrane protein				314
Q8NH60 UniProt NPD GO	O52J3_HUMAN	Olfactory receptor 52J3	0.01	-	end	7 *	Membrane; multi-pass membrane protein				311
Q8NGK3 UniProt NPD GO	O52K2_HUMAN	Olfactory receptor 52K2	0.01	-	end	7 *	Membrane; multi-pass membrane protein				314
Q8NH56 UniProt NPD GO	O52N5_HUMAN	Olfactory receptor 52N5	0.01	-	end	7 *	Membrane; multi-pass membrane protein				324
Q8NGF1 UniProt NPD GO	O52R1_HUMAN	Olfactory receptor 52R1	0.01	-	end	7 *	Membrane; multi-pass membrane protein				315
Q8NGJ0 UniProt NPD GO	OR5A1_HUMAN	Olfactory receptor 5A1 (OST181)	0.01	-	end	7 *	Membrane; multi-pass membrane protein				315
Q8NGP9 UniProt NPD GO	O5AR1_HUMAN	Olfactory receptor 5AR1	0.01	-	end	7 *	Membrane; multi-pass membrane protein				310
Q8NGL3 UniProt NPD GO	OR5DE_HUMAN	Olfactory receptor 5D14	0.01	-	end	7 *	Membrane; multi-pass membrane protein				314
Q8NGV6 UniProt NPD GO	OR5H6_HUMAN	Olfactory receptor 5H6	0.01	-	end	7 *	Membrane; multi-pass membrane protein				309
Q8NHB8 UniProt NPD GO	OR5K2_HUMAN	Olfactory receptor 5K2 (Olfactory receptor OR3-9)	0.01	-	end	5 *	Membrane; multi-pass membrane protein				316
Q8NGP4 UniProt NPD GO	OR5M3_HUMAN	Olfactory receptor 5M3 (Olfactory receptor OR11-191)	0.01	-	end	6 *	Membrane; multi-pass membrane protein				307
Q8WZ94 UniProt NPD GO	OR5P3_HUMAN	Olfactory receptor 5P3 (Olfactory receptor-like protein JCG1)	0.01	-	end	7 *	Membrane; multi-pass membrane protein				311
Q8NH69 UniProt NPD GO	OR5W2_HUMAN	Olfactory receptor 5W2 (Olfactory receptor OR11-155)	0.01	-	end	7 *	Membrane; multi-pass membrane protein				310
P34986 UniProt NPD GO	OLF6_MOUSE	Olfactory receptor 6 (Olfactory receptor 103-16) (Odorant receptor M50)	0.01	-	end	7 *	Membrane; multi-pass membrane protein				316
Q8NGQ2 UniProt NPD GO	OR6Q1_HUMAN	Olfactory receptor 6Q1	0.01	-	end	7 *	Membrane; multi-pass membrane protein				317
Q8NH79 UniProt NPD GO	OR6X1_HUMAN	Olfactory receptor 6X1 (Olfactory receptor OR11-270)	0.01	-	end	7 *	Membrane; multi-pass membrane protein				312
O76100 UniProt NPD GO	OR7AA_HUMAN	Olfactory receptor 7A10 (OST027) (Olfactory receptor OR19-18)	0.01	-	end	7 *	Membrane; multi-pass membrane protein				309
Q8NG98 UniProt NPD GO	OR7D4_HUMAN	Olfactory receptor 7D4 (Olfactory receptor OR19-7)	0.01	-	end	7 *	Membrane; multi-pass membrane protein				312
Q8NG95 UniProt NPD GO	OR7G3_HUMAN	Olfactory receptor 7G3 (OST085)	0.01	-	end	7 *	Membrane; multi-pass membrane protein				312
Q96RC9 UniProt NPD GO	OR8B4_HUMAN	Olfactory receptor 8B4	0.01	-	end	7 *	Membrane; multi-pass membrane protein				309
Q9GZM6 UniProt NPD GO	OR8D2_HUMAN	Olfactory receptor 8D2 (Olfactory receptor-like protein JCG2)	0.01	-	end	7 *	Membrane; multi-pass membrane protein				311
Q98913 UniProt NPD GO	OLF8_CHICK	Olfactory receptor-like protein COR8 (Fragment)	0.01	-	nuc	3 *	Membrane; multi-pass membrane protein				159
Q26418 UniProt NPD GO	OLF3_APILI	Olfactory receptor-like protein HbT3 (Fragment)	0.01	-	end	2 *	Membrane; multi-pass membrane protein (Probable)				168
P48623 UniProt NPD GO	FAD3E_ARATH	Omega-3 fatty acid desaturase, endoplasmic reticulum (EC 1.14.19.-)	0.01	-	end	3	Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein				386

You are viewing entries 90001 to 90050 of 98716. You can see more proteins by changing the limits in the form at the top of this page, or click here for the next page of proteins .

If you find NucPred useful, please cite this paper:

NucPred - Predicting Nuclear Localization of Proteins. Brameier M, Krings A, Maccallum RM. Bioinformatics, 2007. PubMed id: 17332022

The authors also look forward to your comments and suggestions.

What does the NucPred score mean?

You have to decide on a NucPred score threshold. Sequences which score greater than or equal to this threshold are predicted to spend some time in the nucleus. Higher thresholds yield fewer predicted nuclear proteins, but these predictions are more accurate (you can have higher confidence in them). The table below gives more details of the performance of NucPred estimated using the sequences it was trained on (by cross-validation). Another benchmark is available in the Bioinformatics 2007 paper.

NucPred score threshold	Specificity	Sensitivity
see above	fraction of proteins predicted to be nuclear that actually are nuclear	fraction of true nuclear proteins that are predicted (coverage)
0.10	0.45	0.88
0.20	0.52	0.83
0.30	0.57	0.77
0.40	0.63	0.69
0.50	0.70	0.62
0.60	0.71	0.53
0.70	0.81	0.44
0.80	0.84	0.32
0.90	0.88	0.21
1.00	1.00	0.02

Sequences which score >= 0.8 with NucPred and which are predicted by PredictNLS to contain an NLS have been shown to be 93% correct with a coverage of 16%. (PredictNLS by itself is 87% correct with 26% coverage on the same data.)

Go back to the NucPred Home Page.