 | Authors: Amine Heddad, Andrea Krings, Markus Brameier and Bob MacCallum, Stockholm Bioinformatics Center, Stockholm University, Sweden. |
NucPred
Fetching P11530 from www.uniprot.org...
The NucPred score for your sequence is 0.98 (see score help below)
1 MLWWEEVEDCYEREDVQKKTFTKWINAQFSKFGKQHIDNLFSDLQDGKRL 50
51 LDLLEGLTGQKLPKEKGSTRVHALNNVNKALQVLQKNNVDLVNIGSTDIV 100
101 DGNHKLTLGLIWNIILHWQVKNVMKTIMAGLQQTNSEKILLSWVRESTRN 150
151 YPQVNVLNFTSSWSDGLALNALIHSHRPDLFDWNSVVSQQSATQRLEHAF 200
201 NIAKCQLGIEKLLDPEDVATTYPDKKSILMYITSLFQVLPQQVSIEAIRE 250
251 VEMLPRPSKVTREEHFQLHHQMHYSQQITVSLAQGYEQTSSSPKPRFKSY 300
301 AFTQAAYVATSDSSQSPYPSQHLEAPGSKSFGSSLIETEVNLDSYQTALE 350
351 EVLSWLLSAEDTLRAQGEISKDVEEVKEQFHAHEGFMMDLTSHQGLVGNV 400
401 LQLGSRLVGKGKLTEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHKVL 450
451 MDLQNQKLKELDDWLTKTEERTKKMEEEPLGPDLEDLKCQVQQHKVLQED 500
501 LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICKWTED 550
551 RWILLQDILLKWQRFTEEQCLFSKWLSEKEDAMKNIQTSGFEDQNEMVSS 600
601 LQNISALKIDLEKKKQSMEKLSSLNQDLLSALKNKSVTQKMEMWMENFAQ 650
651 RWDNLTQKLEKSSAQISQAVTTTQPSLTQTTVMETVTMVTTREQIMVKHA 700
701 QEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSSEFAV 750
751 YRKEGNISDLKEKVNAIAREKAEKFRKLQDASRSAQALVEQMVNEGVNAE 800
801 SIRQASEQLNSRWTEFCQLLSERVNWLEYQNNIITFYNQLQQLEQMTTTA 850
851 ENLLKTQPTTLSEPTAIKSQLKICKDEVNRLSALQPQIERLKIQSLTLKE 900
901 KGQGPMFLDADFVAFTNHFNYVFDGVRAREKELQTIFDTLPPMRYQETMS 950
951 SIRTWIQQSENKLSIPHLSVTEYEIMEERLGKLQALQSSLKEQQNGFNYL 1000
1001 NATVKEIAKKAPSEISQKYQSEFEEVEGRWKKLSTQLVEHCQKLEEHMNK 1050
1051 LRKFQNHKKTLQKWMAEVDVFLKEEWPALGDAEILKKQLKQCRLLVGDIQ 1100
1101 TIQPSLNSVNEGGQKIKSEAEFEFASRLEKELKELNTQWDHICRQVYTRK 1150
1151 EALKAGLDKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQTAVEE 1200
1201 MKRAKEEALQKEAKVKLLTETVNSVISQAPPAAQEALKKELETLTTNYQW 1250
1251 LCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVELKLKATENVPAGA 1300
1301 EEITEVLESLENLMHHSEENPNQIRLLAQTLTDGGVMDELINEELETFNS 1350
1351 RWRELHEEAVRKQKLLEQSIQSAQEIEKSLHLIQESLEFIDKQLAAYIAD 1400
1401 KVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKDANQRVLSQIDVAQK 1450
1451 KLQDVSIKFRLFQKPANFEQRLEESKMILDEVKMHLPALETKSVEQEVVQ 1500
1501 SQLSHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALK 1550
1551 LHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDTELTKRSA 1600
1601 VEGMPSNLDSEVAWGKATQKEIEKQKAHLKSVTELGDSLKTVLGKKETLV 1650
1651 EDKLTLLNSNWIAVTSRVEEWLNLLLEYQKHMESFDQNVEHITKWIIHTD 1700
1701 ELLDESEKRKPQQKEDILKRLKAEMNDIRPKVDATRDQAAKLMANRGDYC 1750
1751 RKIVEPQISELNRRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEA 1800
1801 EIQQGVNLKEEDFNKDMSEDNEGTVNELLQRGDNLQQRITDERKREEIKL 1850
1851 KQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKSQADDLLKCLDEIEKK 1900
1901 LASLPEPRDERKIKEIDRELQKKKEELNAVRRQAESLSENGAAMAVEPTQ 1950
1951 IQLSKRWREIESNFAQFRRLNFAQIHTLHEETMVVTTEDMPLDVSYVPST 2000
2001 YLTEISHILQALSEVEQLLNAPELNAKDFEDLFKQEESLKNIKENLQQIS 2050
2051 GRIDVIHKKKTAALQSATPMERVKLQEAVSQMDFHWEKLNRMYKERQGRF 2100
2101 DRSVEKWRHFHYDMKVFNQWLNDVEQFFKKTQNPENWEHAKYKWYLKELQ 2150
2151 DGIGQRQAVVRTLNATGEEIIQQSSKTDANILQEKLGSLSLRWHEVCKEL 2200
2201 AERRKRVEEQKNVFSEFQRDLNEFVSWLEEADNIATTPPGDEEQLKEKLE 2250
2251 QVKLLTEELPLRQGILKQLNETGGAVLVSAPIRPEEQDKLEKKLKQTNLQ 2300
2301 WIKVSRALPEKQGELEVHIKDFRQFEEQLDHLLLWLSPIRNQLEIYNQPS 2350
2351 QPGPFDLKETEVTVQAKQPDVERLLSKGQHLYKEKPSTQPVKRKLEDLRS 2400
2401 EWEAVNHLLWELRTKQPDRAPGLSTTGASASQTVTVVTQPVDTKETVISK 2450
2451 LEMPSSLLLEVPALADFNRAWTELTDWLSLLDRVIKSQRVMVGDLEDINE 2500
2501 MIIKQKATLQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 2550
2551 IQWDEVQEQLQNRRQQLNEMLKDSTQWLEAKEEAEQVIGQARGKLDSWKE 2600
2601 GPHTMDAIQKKITETKQLAKDLRQRQINVDVANDLALKLLRDYSADDTRK 2650
2651 VHMITENINTSWGNILKRVSEREAALEETQRLLQQFPLDLEKFLAWITEA 2700
2701 ETTANVLQDASRKEKLLEDSRGVRELMKPWQDLQGEIEAHTDIYHNLDEN 2750
2751 GQKILRSLEGSDEAPLLQRRLDNMNFKWSELRKKSLNIRSHLEVSSDQWK 2800
2801 RLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 2850
2851 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 2900
2901 EEVNTEWDKLNLHSADWQRKIDEALERLQELQEAADELDLKLRQAEVIKG 2950
2951 SWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVNHVNDLAHHLTTLGIQ 3000
3001 LSPYNLSILEDLNTRWRLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQ 3050
3051 GPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRT 3100
3101 AMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 3150
3151 DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCK 3200
3201 AHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSN 3250
3251 IEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAK 3300
3301 HQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVE 3350
3351 YCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET 3400
3401 PVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDS 3450
3451 ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELER 3500
3501 ILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAEL 3550
3551 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNG 3600
3601 TTVSSPSTSLQRSDSSQPMLLRVVGSQTSESMGEEDLLSPPQDTSTGLEE 3650
3651 VMEQLNNSFPSSRGRNAPGKPMREDTM 3677
Positively and negatively influencing subsequences are coloured according to the following scale:
(non-nuclear) negative ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| positive (nuclear)
What does the NucPred score mean?
| You have to decide on a NucPred score threshold. Sequences which score greater than or equal to this threshold are predicted to spend some time in the nucleus. Higher thresholds yield fewer predicted nuclear proteins, but these predictions are more accurate (you can have higher confidence in them). The table below gives more details of the performance of NucPred estimated using the sequences it was trained on (by cross-validation). Another benchmark is available in the Bioinformatics 2007 paper. |
| NucPred score threshold | Specificity | Sensitivity |
| see above | fraction of proteins predicted to be nuclear that actually are nuclear | fraction of true nuclear proteins that are predicted (coverage) |
| 0.10 | 0.45 | 0.88 |
| 0.20 | 0.52 | 0.83 |
| 0.30 | 0.57 | 0.77 |
| 0.40 | 0.63 | 0.69 |
| 0.50 | 0.70 | 0.62 |
| 0.60 | 0.71 | 0.53 |
| 0.70 | 0.81 | 0.44 |
| 0.80 | 0.84 | 0.32 |
| 0.90 | 0.88 | 0.21 |
| 1.00 | 1.00 | 0.02 |
| Sequences which score >= 0.8 with NucPred and which
are predicted by PredictNLS to contain an NLS have been shown to be 93% correct with a coverage of 16%. (PredictNLS by itself is 87% correct with 26% coverage on the same data.) |
Go back to the NucPred Home Page.