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Patterns of hydrophobicity and sequence conservation are widely used to
predict secondary structure (see Chapter 1). Whilst the
predicted secondary structure cannot contain any more information than is
already available in multiple sequences, it seems that this derived
information is effective in fold
recognition[Taylor & Thornton, 1984,Fischer & Eisenberg, 1996,Defay & Cohen, 1996,Hubbard & Park, 1995,Rice & Eisenberg, 1997,Rost et al., 1997].
This is in spite of only about 70% average 
accuracy. Furthermore,
Russell et al.russell:jmb97 also showed that secondary
structure predictions agree for only about 65% of structurally equivalent
residues in pairs of remote homologues and analogues. This result is
particularly relevant to this work.