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The FSSP database of the Sander group[Holm & Sander, 1994] uses the DALI structure comparison program to define a non-redundant set of protein structures from the PDB. It does not currently consider domains as separate entities. This database can be searched with a newly solved structure as the query, allowing crystallographers and NMR spectroscopists to draw parallels to the structures and functions of known proteins of which they are unaware.