![]() | Authors: Andrea Krings, Amine Heddad, Markus Brameier and Bob MacCallum, Stockholm Bioinformatics Center, Stockholm University, Sweden. |
UniProt accession | UniProt ID | UniProt description | NucPred score | Predict- NLS | PSORT II | TMHMM #helices | UniProt annotation for subcellular location | Uniprot GO cellular component | OMIM | PDB | sequence length |
P38854 UniProt NPD GO | YHV9_YEAST | Uncharacterized protein YHR159W | 0.93 | - | nuc | 0 | cytoplasm [IDA] | 504 | |||
P38870 UniProt NPD GO | YHY2_YEAST | Uncharacterized protein YHR182W | 0.93 | - | nuc | 0 | cytoplasm [IDA] | 785 | |||
P40498 UniProt NPD GO | YIJ1_YEAST | Uncharacterized protein YIL091C | 0.93 | - | nuc | 0 | nucleolus [IDA] nucleus [IDA] | 721 | |||
Q99299 UniProt NPD GO | YP158_YEAST | Uncharacterized protein YPL158C | 0.93 | + | nuc | 0 | bud neck [IDA] | 758 | |||
Q03944 UniProt NPD GO | VPS64_YEAST | Vacuolar protein sorting protein 64 (Factor arrest protein 9) | 0.93 | - | nuc | 0 | Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass type IV membrane protein (Potenti ... | cytoplasm [IDA] endoplasmic reticulum membrane [IDA] | 604 | ||
P16612 UniProt NPD GO | VEGFA_RAT | Vascular endothelial growth factor A precursor (VEGF-A) (Vascular permeability factor) (VPF) | 0.93 | + | nuc | 0 | Secreted protein (By similarity). VEGF-A120 is acidic and freely secreted. VEGF-A164 is more basic, ... | 214 | |||
Q8C761 UniProt NPD GO | WDR60_MOUSE | WD repeat protein 60 | 0.93 | + | nuc | 0 | 999 | ||||
P48234 UniProt NPD GO | YG3J_YEAST | WD repeat protein YGR145W | 0.93 | + | nuc | 0 | nucleolus [IDA] | 707 | |||
Q03177 UniProt NPD GO | YMZ2_YEAST | WD repeat protein YMR102C | 0.93 | + | nuc | 0 | 834 | ||||
P46941 UniProt NPD GO | YLE5_CAEEL | WW domain-containing protein C38D4.5 | 0.93 | - | nuc | 0 | 837 | ||||
O09053 UniProt NPD GO | WRN_MOUSE | Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-) | 0.93 | - | nuc | 0 | Nucleus | 1401 | |||
Q99MZ3 UniProt NPD GO | WBS14_MOUSE | Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting prot ... | 0.93 | - | nuc | 0 | Nucleus (By similarity) | transcription factor complex [IDA] | 864 | ||
Q8VHI6 UniProt NPD GO | WASF3_MOUSE | Wiskott-Aldrich syndrome protein family member 3 (WASP-family protein member 3) (Protein WAVE-3) | 0.93 | + | nuc | 0 | Cytoplasm (By similarity) | 501 | |||
P25992 UniProt NPD GO | YEMA_DROME | Yemanuclein-alpha | 0.93 | + | nuc | 0 | Nucleus | nucleus [TAS] | 1002 | ||
Q66IH9 UniProt NPD GO | ZCHC4_XENTR | Zinc finger CCHC domain-containing protein 4 | 0.93 | + | nuc | 0 | 487 | ||||
Q8NAP3 UniProt NPD GO | ZBT38_HUMAN | Zinc finger and BTB domain-containing protein 38 | 0.93 | - | nuc | 0 | Nucleus (By similarity) | nucleus [ISS] | 1195 | ||
Q4R361 UniProt NPD GO | ZN645_MACFA | Zinc finger protein 645 | 0.93 | - | nuc | 0 | 422 | ||||
Q9BU19 UniProt NPD GO | ZN692_HUMAN | Zinc finger protein 692 | 0.93 | + | nuc | 0 | Nucleus (Probable) | 519 | |||
Q3U381 UniProt NPD GO | ZN692_MOUSE | Zinc finger protein 692 | 0.93 | + | nuc | 0 | Nucleus (Probable) | 531 | |||
P55879 UniProt NPD GO | GLI3_CHICK | Zinc finger protein GLI3 (Fragment) | 0.93 | - | nuc | 0 | Nucleus | 663 | |||
Q91661 UniProt NPD GO | GLI4_XENLA | Zinc finger protein GLI4 (Neural-specific DNA-binding protein xGLI4) (xGLI-4) | 0.93 | - | nuc | 0 | Nucleus (Potential) | 1361 | |||
O35615 UniProt NPD GO | FOG1_MOUSE | Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GA ... | 0.93 | - | nuc | 0 | Nucleus | nucleus [IDA] | 1SRK | 995 | |
P51984 UniProt NPD GO | CREB_CHLVR | cAMP response element-binding protein | 0.93 | + | nuc | 0 | Nucleus | 249 | |||
Q5AM44 UniProt NPD GO | RNA14_CANAL | mRNA 3'-end processing protein RNA14 | 0.93 | - | nuc | 0 | Nucleus (By similarity). Cytoplasm (By similarity). Nucleus and/or cytoplasm (By similarity) | 791 | |||
Q5KU05 UniProt NPD GO | PALA_ASPOR | pH-response regulator protein palA/RIM20 | 0.93 | - | nuc | 0 | 828 | ||||
Q873Y3 UniProt NPD GO | PACC_CANDU | pH-response transcription factor pacC/RIM101 | 0.93 | - | nuc | 0 | Cytoplasm (By similarity). Nucleus (By similarity) | 666 | |||
Q870A3 UniProt NPD GO | PACC_FUSOX | pH-response transcription factor pacC/RIM101 | 0.93 | - | nuc | 0 | Cytoplasm (By similarity). Nucleus (By similarity) | 609 | |||
Q9UW14 UniProt NPD GO | PACC_CANAL | pH-response transcription factor pacC/RIM101 (pH-response regulator protein 2) | 0.93 | - | nuc | 0 | Cytoplasm (By similarity). Nucleus (By similarity) | 661 | |||
Q96NA8 UniProt NPD GO | TSNA1_HUMAN | t-SNARE domain-containing protein 1 | 0.93 | - | nuc | 1 | 513 | ||||
Q2T9V5 UniProt NPD GO | TRM6_BOVIN | tRNA (adenine-N(1)-)-methyltransferase non-catalytic subunit TRM6 (tRNA(m1A58)-methyltransferase sub ... | 0.93 | + | nuc | 0 | Nucleus (By similarity) | 497 | |||
Q8IZH2 UniProt NPD GO | XRN1_HUMAN | 5'-3' exoribonuclease 1 (EC 3.1.11.-) (Strand-exchange protein 1 homolog) | 0.92 | - | nuc | 0 | Cytoplasm. Discrete foci at the inner surface of the cell membrane | 607994 | 1706 | ||
Q62924 UniProt NPD GO | AKA11_RAT | A-kinase anchor protein 11 (Protein kinase A-anchoring protein 11) (PRKA11) (A-kinase anchor protein ... | 0.92 | + | nuc | 0 | Peroxisome | peroxisome [IDA] | 1129 | ||
O43823 UniProt NPD GO | AKAP8_HUMAN | A-kinase anchor protein 8 (A-kinase anchor protein 95 kDa) (AKAP 95) | 0.92 | + | nuc | 0 | Nucleus; nucleoplasm; nuclear matrix. Associated with the nuclear matrix. Redistributed and detached ... | nucleus [TAS] | 604692 | 692 | |
Q9R0L7 UniProt NPD GO | AKP8L_MOUSE | A-kinase anchor protein 8-like (AKAP8-like protein) (Neighbor of A-kinase-anchoring protein 95) (Nei ... | 0.92 | + | nuc | 0 | Nucleus; nucleoplasm; nuclear matrix (By similarity). Cytoplasm (By similarity). Nuclear at steady s ... | 642 | |||
P14196 UniProt NPD GO | AAC2_DICDI | AAC-rich mRNA clone AAC11 protein (Fragment) | 0.92 | + | nuc | 0 | 448 | ||||
Q9Y2X7 UniProt NPD GO | GIT1_HUMAN | ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase-interactor 1) (GRK-interacting ... | 0.92 | - | nuc | 0 | Cytoplasm. Cycles between at least 3 distinct intracellular compartments, including focal adhesions, ... | 608434 | 761 | ||
Q8BM75 UniProt NPD GO | ARI5B_MOUSE | AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (MRF1-like) (Mo ... | 0.92 | - | nuc | 0 | Nucleus | 1188 | |||
Q6FNA2 UniProt NPD GO | DBP10_CANGA | ATP-dependent RNA helicase DBP10 (EC 3.6.1.-) | 0.92 | + | nuc | 0 | Nucleus; nucleolus (By similarity) | 969 | |||
Q6CIR0 UniProt NPD GO | DBP10_KLULA | ATP-dependent RNA helicase DBP10 (EC 3.6.1.-) | 0.92 | + | nuc | 0 | Nucleus; nucleolus (By similarity) | 973 | |||
Q6BXG0 UniProt NPD GO | DBP4_DEBHA | ATP-dependent RNA helicase DBP4 (EC 3.6.1.-) | 0.92 | + | nuc | 0 | Nucleus; nucleolus (By similarity) | 766 | |||
Q8K4L0 UniProt NPD GO | DDX54_MOUSE | ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54) | 0.92 | + | nuc | 0 | Nucleus; nucleolus (By similarity) | nucleolus [ISS] nucleus [ISS] | 874 | ||
P38112 UniProt NPD GO | MAK5_YEAST | ATP-dependent RNA helicase MAK5 (EC 3.6.1.-) (Maintenance of killer protein 5) | 0.92 | - | nuc | 0 | Nucleus; nucleolus | nucleolus [IDA] | 773 | ||
Q2UHC1 UniProt NPD GO | DBP10_ASPOR | ATP-dependent RNA helicase dbp10 (EC 3.6.1.-) | 0.92 | + | nuc | 0 | Nucleus; nucleolus (By similarity) | 929 | |||
Q2UE66 UniProt NPD GO | DBP7_ASPOR | ATP-dependent RNA helicase dbp7 (EC 3.6.1.-) | 0.92 | + | nuc | 0 | Nucleus; nucleolus (By similarity) | 760 | |||
O60173 UniProt NPD GO | DBP7_SCHPO | ATP-dependent RNA helicase dbp7 (EC 3.6.1.-) | 0.92 | - | nuc | 0 | Nucleus; nucleolus (By similarity) | 709 | |||
Q4WRH5 UniProt NPD GO | ROK1_ASPFU | ATP-dependent RNA helicase rok1 (EC 3.6.1.-) | 0.92 | + | nuc | 0 | Nucleus; nucleolus (By similarity) | 739 | |||
Q2UQW3 UniProt NPD GO | ROK1_ASPOR | ATP-dependent RNA helicase rok1 (EC 3.6.1.-) | 0.92 | + | nuc | 0 | Nucleus; nucleolus (By similarity) | 725 | |||
Q5BET6 UniProt NPD GO | ROK1_EMENI | ATP-dependent RNA helicase rok1 (EC 3.6.1.-) | 0.92 | + | nuc | 0 | Nucleus; nucleolus (By similarity) | 742 | |||
Q59N29 UniProt NPD GO | SPB41_CANAL | ATP-dependent rRNA helicase SPB41 (EC 3.6.1.-) | 0.92 | + | nuc | 0 | Nucleus; nucleolus (By similarity) | 631 | |||
Q59NP8 UniProt NPD GO | SPB42_CANAL | ATP-dependent rRNA helicase SPB42 (EC 3.6.1.-) | 0.92 | + | nuc | 0 | Nucleus; nucleolus (By similarity) | 631 |
You are viewing entries 3101 to 3150 of 98716. You can see more proteins by changing the limits in the form at the top of this page, or click here for the next page of proteins .
If you find NucPred useful, please cite this paper:
NucPred - Predicting Nuclear Localization of Proteins. Brameier M, Krings A, Maccallum RM. Bioinformatics, 2007. PubMed id: 17332022The authors also look forward to your comments and suggestions. |
You have to decide on a NucPred score threshold. Sequences which score greater than or equal to this threshold are predicted to spend some time in the nucleus. Higher thresholds yield fewer predicted nuclear proteins, but these predictions are more accurate (you can have higher confidence in them). The table below gives more details of the performance of NucPred estimated using the sequences it was trained on (by cross-validation). Another benchmark is available in the Bioinformatics 2007 paper. |
NucPred score threshold | Specificity | Sensitivity |
see above | fraction of proteins predicted to be nuclear that actually are nuclear | fraction of true nuclear proteins that are predicted (coverage) |
0.10 | 0.45 | 0.88 |
0.20 | 0.52 | 0.83 |
0.30 | 0.57 | 0.77 |
0.40 | 0.63 | 0.69 |
0.50 | 0.70 | 0.62 |
0.60 | 0.71 | 0.53 |
0.70 | 0.81 | 0.44 |
0.80 | 0.84 | 0.32 |
0.90 | 0.88 | 0.21 |
1.00 | 1.00 | 0.02 |
Sequences which score >= 0.8 with NucPred and which are predicted by PredictNLS to contain an NLS have been shown to be 93% correct with a coverage of 16%. (PredictNLS by itself is 87% correct with 26% coverage on the same data.) |