Authors: Andrea Krings, Amine Heddad, Markus Brameier and Bob MacCallum, Stockholm Bioinformatics Center, Stockholm University, Sweden. |
UniProt accession | UniProt ID | UniProt description | NucPred score | Predict- NLS | PSORT II | TMHMM #helices | UniProt annotation for subcellular location | Uniprot GO cellular component | OMIM | PDB | sequence length |
Q9NVP1 UniProt NPD GO | DDX18_HUMAN | ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18) (Myc-regulated DEAD box protein) ... | 0.90 | + | nuc | 0 | 606355 | 670 | |||
P11274 UniProt NPD GO | BCR_HUMAN | Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen) | 0.90 | + | nuc | 0 | 151410 | 1K1F | 1271 | ||
Q96L91 UniProt NPD GO | EP400_HUMAN | E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino ... | 0.90 | + | nuc | 0 | 606265 | 3160 | |||
Q9UEY8 UniProt NPD GO | ADDG_HUMAN | Gamma-adducin (Adducin-like protein 70) | 0.90 | + | nuc | 0 | membrane [TAS] | 601568 | 706 | ||
Q8N3R9 UniProt NPD GO | MPP5_HUMAN | MAGUK p55 subfamily member 5 | 0.90 | + | nuc | 0 | Cell membrane; peripheral membrane protein. Intracellular membrane; peripheral membrane protein. Loc ... | 606958 | 1Y76 | 675 | |
Q99569 UniProt NPD GO | PKP4_HUMAN | Plakophilin-4 (p0071) | 0.90 | + | nuc | 0 | Cell membrane; cell-cell junction; desmosome. Colocalized with desmoplakin at desmosomal junctional ... | intercellular junction [TAS] | 604276 | 1211 | |
Q9NQ29 UniProt NPD GO | LUC7L_HUMAN | Putative RNA-binding protein Luc7-like 1 (SR+89) (Putative SR protein LUC7B1) | 0.90 | + | nuc | 0 | 607782 | 371 | |||
Q96J92 UniProt NPD GO | WNK4_HUMAN | Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase ... | 0.90 | + | nuc | 0 | Cell membrane; cell-cell junction; tight junction (By similarity). Present exclusively in intercellu ... | tight junction [ISS] | 601844 | 1243 | |
O00294 UniProt NPD GO | TULP1_HUMAN | Tubby-related protein 1 (Tubby-like protein 1) | 0.90 | + | nuc | 0 | 600132 | 2FIM | 542 | ||
Q7Z406 UniProt NPD GO | MYH14_HUMAN | Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C) | 0.89 | + | nuc | 0 | 608568 | 1995 | |||
P35579 UniProt NPD GO | MYH9_HUMAN | Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC- ... | 0.89 | + | nuc | 0 | 605249 | 1959 | |||
Q8N4C6 UniProt NPD GO | NIN_HUMAN | Ninein (hNinein) | 0.89 | + | nuc | 0 | Centrosome. Component of the core centrosome. Arranged in a tubular conformation with an open and a ... | centrosome [IDA] | 608684 | 2090 | |
Q6ZMN7 UniProt NPD GO | PZRN4_HUMAN | PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein) | 0.89 | + | nuc | 0 | 609730 | 1036 | |||
O75781 UniProt NPD GO | PALM_HUMAN | Paralemmin | 0.89 | + | nuc | 0 | Membrane; peripheral membrane protein (By similarity) | cytoplasmic membrane-bound vesicle [TAS] integral to plasma membrane [TAS] plasma membrane [NAS] | 608134 | 387 | |
Q14644 UniProt NPD GO | RASA3_HUMAN | Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) | 0.89 | + | nuc | 0 | Cell membrane | plasma membrane [TAS] | 605182 | 834 | |
Q9NR80 UniProt NPD GO | ARHG4_HUMAN | Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef) | 0.89 | + | nuc | 0 | Isoform 3: Cytoplasm. Associated with membrane ruffles (Probable) | 605216 | 657 | ||
Q96QB1 UniProt NPD GO | RHG07_HUMAN | Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 pr ... | 0.89 | + | nuc | 0 | Cytoplasm (Potential) | cytoplasm [NAS] | 604258 | 1091 | |
Q9P0W8 UniProt NPD GO | SPAT7_HUMAN | Spermatogenesis-associated protein 7 (Spermatogenesis-associated protein HSD3) (HSD-3.1) | 0.89 | + | nuc | 0 | 609868 | 599 | |||
O95872 UniProt NPD GO | BAT4_HUMAN | Protein BAT4 (HLA-B-associated transcript 4) (G5 protein) | 0.88 | + | nuc | 0 | 142610 | 356 | |||
Q7RTP6 UniProt NPD GO | MICA3_HUMAN | Protein MICAL-3 | 0.88 | + | nuc | 0 | Cytoplasm (By similarity) | 608882 | 976 | ||
P45379 UniProt NPD GO | TNNT2_HUMAN | Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT) | 0.88 | + | nuc | 0 | 115195 | 1J1E | 297 | ||
Q15147 UniProt NPD GO | PLCB4_HUMAN | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide pho ... | 0.87 | + | nuc | 0 | 600810 | 1175 | |||
P12259 UniProt NPD GO | FA5_HUMAN | Coagulation factor V precursor (Activated protein C cofactor) [Contains: Coagulation factor V heavy ... | 0.87 | + | nuc | 0 | extracellular region [NAS] | 188055 | 1FV4 | 2224 | |
P11387 UniProt NPD GO | TOP1_HUMAN | DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I) | 0.87 | + | nuc | 0 | 126420 | 1TL8 | 765 | ||
O60841 UniProt NPD GO | IF2P_HUMAN | Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2) | 0.87 | + | nuc | 0 | 606086 | 1220 | |||
Q99558 UniProt NPD GO | M3K14_HUMAN | Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa beta-inducing kinase) (Se ... | 0.87 | + | nuc | 0 | Cytoplasm | 604655 | 947 | ||
Q9UHJ3 UniProt NPD GO | SMBT1_HUMAN | Scm-like with four MBT domains protein 1 (Renal ubiquitous protein 1) | 0.87 | + | nuc | 0 | 607319 | 866 | |||
Q8N103 UniProt NPD GO | TAGAP_HUMAN | T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein) | 0.87 | + | nuc | 0 | 609667 | 731 | |||
Q92558 UniProt NPD GO | WASF1_HUMAN | Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Ve ... | 0.87 | + | nuc | 0 | Cytoplasm. Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas | actin cytoskeleton [TAS] | 605035 | 559 | |
Q07343 UniProt NPD GO | PDE4B_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32) | 0.87 | + | nuc | 0 | insoluble fraction [TAS] soluble fraction [TAS] | 600127 | 2CHM | 736 | |
P84098 UniProt NPD GO | RL19_HUMAN | 60S ribosomal protein L19 | 0.86 | + | nuc | 0 | 180466 | 196 | |||
P23508 UniProt NPD GO | CRCM_HUMAN | Colorectal mutant cancer protein (Protein MCC) | 0.86 | + | nuc | 0 | 159350 | 829 | |||
P78563 UniProt NPD GO | RED1_HUMAN | Double-stranded RNA-specific editase 1 (EC 3.5.-.-) (dsRNA adenosine deaminase) (RNA-editing deamina ... | 0.86 | + | nuc | 0 | 601218 | 1ZY7 | 741 | ||
Q9UPT5 UniProt NPD GO | EXOC7_HUMAN | Exocyst complex component 7 (Exocyst complex component Exo70) | 0.86 | + | nuc | 0 | Cytoplasm; cytosol (By similarity). Cell membrane; peripheral membrane protein (By similarity). Tran ... | 608163 | 735 | ||
Q86UP2 UniProt NPD GO | KTN1_HUMAN | Kinectin (Kinesin receptor) (CG-1 antigen) | 0.86 | + | nuc | 1 * | Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass type II membrane protein. Vesicle ... | endoplasmic reticulum membrane [ISS] | 600381 | 1357 | |
Q15149 UniProt NPD GO | PLEC1_HUMAN | Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1) | 0.86 | + | nuc | 0 | plasma membrane [NAS] | 131950 | 1MB8 | 4684 | |
Q9NYF5 UniProt NPD GO | CE005_HUMAN | Protein C5orf5 (GAP-like protein N61) | 0.86 | + | nuc | 0 | 609371 | 915 | |||
Q92997 UniProt NPD GO | DVL3_HUMAN | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | 0.86 | + | nuc | 0 | Cytoplasm (By similarity) | 601368 | 716 | ||
Q8NE71 UniProt NPD GO | ABCF1_HUMAN | ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50) (TNF-alpha-stimulated ABC prote ... | 0.85 | + | nuc | 0 | 603429 | 845 | |||
Q9UMZ2 UniProt NPD GO | SYNG_HUMAN | AP1 subunit gamma-binding protein 1 (Gamma-synergin) | 0.84 | + | nuc | 0 | Cytoplasm (By similarity). Golgi apparatus; trans-Golgi network; trans-Golgi network membrane; perip ... | AP-1 adaptor complex [TAS] cytoplasm [TAS] Golgi apparatus [TAS] | 607291 | 1314 | |
Q96SN8 UniProt NPD GO | CK5P2_HUMAN | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associ ... | 0.84 | + | nuc | 0 | Centrosome | centrosome [IDA] cytoskeleton [NAS] | 608201 | 1893 | |
Q08379 UniProt NPD GO | GOGA2_HUMAN | Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95) | 0.84 | + | nuc | 0 | Golgi apparatus; Golgi stack; Golgi stack membrane; peripheral membrane protein | Golgi apparatus [IDA] | 602580 | 990 | |
Q969R2 UniProt NPD GO | OSBP2_HUMAN | Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) ( ... | 0.84 | + | nuc | 0 | Membrane; peripheral membrane protein | 606729 | 916 | ||
P78559 UniProt NPD GO | MAP1A_HUMAN | Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light ... | 0.82 | + | nuc | 0 | microtubule associated complex [TAS] | 600178 | 2805 | ||
Q92733 UniProt NPD GO | PRCC_HUMAN | Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein) | 0.82 | + | nuc | 0 | 179755 | 491 | |||
P46940 UniProt NPD GO | IQGA1_HUMAN | Ras GTPase-activating-like protein IQGAP1 (p195) | 0.82 | + | nuc | 0 | Cell membrane | actin filament [TAS] | 603379 | 1X0H | 1657 |
O14640 UniProt NPD GO | DVL1_HUMAN | Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) | 0.82 | + | nuc | 0 | cytoplasm [TAS] | 601365 | 670 | ||
O95025 UniProt NPD GO | SEM3D_HUMAN | Semaphorin-3D precursor | 0.82 | + | nuc | 1 * | Secreted protein (By similarity) | 609907 | 777 | ||
P62241 UniProt NPD GO | RS8_HUMAN | 40S ribosomal protein S8 | 0.81 | + | nuc | 0 | cytosolic small ribosomal subunit (sensu Eu... [IDA] | 600357 | 207 | ||
Q9UEE9 UniProt NPD GO | CFDP1_HUMAN | Craniofacial development protein 1 (Bucentaur) | 0.81 | + | nuc | 0 | 608108 | 299 | |||
O96004 UniProt NPD GO | HAND1_HUMAN | Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic ne ... | 0.81 | + | nuc | 0 | 602406 | 215 | |||
O43491 UniProt NPD GO | E41L2_HUMAN | Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G) | 0.80 | + | nuc | 0 | plasma membrane [TAS] spectrin [TAS] | 603237 | 1005 | ||
P35612 UniProt NPD GO | ADDB_HUMAN | Beta-adducin (Erythrocyte adducin subunit beta) | 0.80 | + | nuc | 0 | 102681 | 725 | |||
O00522 UniProt NPD GO | KRIT1_HUMAN | Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 ... | 0.80 | + | nuc | 0 | Membrane; peripheral membrane protein (Probable) | 604214 | 736 | ||
O43566 UniProt NPD GO | RGS14_HUMAN | Regulator of G-protein signaling 14 (RGS14) | 0.80 | + | nuc | 0 | 602513 | 594 | |||
Q9Y6W5 UniProt NPD GO | WASF2_HUMAN | Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Ve ... | 0.80 | + | nuc | 0 | Cytoplasm (By similarity). At the interface between the lamellipodial actin meshwork and the membran ... | actin cytoskeleton [TAS] | 605875 | 2A40 | 498 |
P46779 UniProt NPD GO | RL28_HUMAN | 60S ribosomal protein L28 | 0.79 | + | nuc | 0 | cytosolic large ribosomal subunit (sensu Eu... [TAS] | 603638 | 136 | ||
P12643 UniProt NPD GO | BMP2_HUMAN | Bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A) | 0.79 | + | nuc | 1 * | Secreted protein | 112261 | 3BMP | 396 | |
O75496 UniProt NPD GO | GEMI_HUMAN | Geminin | 0.79 | + | nuc | 0 | 602842 | 1UII | 209 | ||
P83731 UniProt NPD GO | RL24_HUMAN | 60S ribosomal protein L24 (Ribosomal protein L30) | 0.78 | + | nuc | 0 | 604180 | 157 | |||
P23352 UniProt NPD GO | KALM_HUMAN | Anosmin-1 precursor (Kallmann syndrome protein) (Adhesion molecule-like X-linked) | 0.78 | + | nuc | 0 | Cell surface | extracellular matrix (sensu Metazoa) [TAS] extracellular space [TAS] | 308700 | 1ZLG | 680 |
Q13202 UniProt NPD GO | DUS8_HUMAN | Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phospha ... | 0.78 | + | nuc | 0 | cytoplasm [TAS] | 602038 | 625 | ||
Q9H3P7 UniProt NPD GO | GCP60_HUMAN | Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi phosphoprotein 1) ... | 0.78 | + | nuc | 0 | Golgi apparatus; Golgi membrane; peripheral membrane protein; cytoplasmic side (By similarity). Mito ... | 606809 | 527 | ||
P48506 UniProt NPD GO | GSH1_HUMAN | Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (Gamma-glutamylcysteine synthetase) (Gamma ... | 0.77 | + | nuc | 0 | 606857 | 636 | |||
Q14449 UniProt NPD GO | GRB14_HUMAN | Growth factor receptor-bound protein 14 (GRB14 adapter protein) | 0.77 | + | nuc | 0 | Cytoplasm. Golgi apparatus; Golgi membrane; peripheral membrane protein. Endosome; endosomal membran ... | 601524 | 2AUH | 540 | |
Q9P2E9 UniProt NPD GO | RRBP1_HUMAN | Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-r ... | 0.77 | + | nuc | 1 * | Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass type III membrane protein (By sim ... | endoplasmic reticulum [NAS] integral to endoplasmic reticulum membrane [NAS] ribosome [TAS] | 601418 | 1410 | |
Q9Y5T5 UniProt NPD GO | UBP16_HUMAN | Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.1.2.15) (Ubiquitin thioesterase 16) (Ubiquitin-specif ... | 0.77 | + | nuc | 0 | cytoplasm [TAS] | 604735 | 823 | ||
Q92574 UniProt NPD GO | TSC1_HUMAN | Hamartin (Tuberous sclerosis 1 protein) | 0.76 | + | nuc | 0 | Cytoplasm. Membrane; peripheral membrane protein. At steady state found in association with membrane ... | 607341 | 1164 | ||
P11487 UniProt NPD GO | FGF3_HUMAN | INT-2 proto-oncogene protein precursor (Fibroblast growth factor 3) (FGF-3) (HBGF-3) | 0.76 | + | nuc | 0 | extracellular region [TAS] | 164950 | 239 | ||
O14641 UniProt NPD GO | DVL2_HUMAN | Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) | 0.76 | + | nuc | 0 | Cytoplasm | cytoplasm [TAS] | 602151 | 736 | |
Q14185 UniProt NPD GO | DOCK1_HUMAN | Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) | 0.75 | + | nuc | 0 | Cytoplasm (Probable). Membrane (Probable). Recruited to membranes via its interaction with phosphati ... | cytoplasm [TAS] | 601403 | 1865 | |
Q02577 UniProt NPD GO | HEN2_HUMAN | Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL-2) | 0.75 | + | nuc | 0 | 162361 | 135 | |||
O00291 UniProt NPD GO | HIP1_HUMAN | Huntingtin-interacting protein 1 (HIP-I) | 0.75 | + | nuc | 0 | Intracytoplasmic membrane | cytoplasm [IDA] cytoskeleton [TAS] Golgi apparatus [IDA] membrane fraction [TAS] | 601767 | 1030 | |
Q13309 UniProt NPD GO | SKP2_HUMAN | S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (p45 ... | 0.75 | + | nuc | 0 | 601436 | 2AST | 424 | ||
Q14123 UniProt NPD GO | PDE1C_HUMAN | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) ... | 0.74 | + | nuc | 0 | 602987 | 1LXS | 709 | ||
P20042 UniProt NPD GO | IF2B_HUMAN | Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 sub ... | 0.74 | + | nuc | 0 | eukaryotic translation initiation factor 2 ... [TAS] | 603908 | 333 | ||
Q9HCP0 UniProt NPD GO | KC1G1_HUMAN | Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1) | 0.73 | + | nuc | 0 | Cytoplasm | 606274 | 2CMW | 422 | |
Q9Y4H2 UniProt NPD GO | IRS2_HUMAN | Insulin receptor substrate 2 (IRS-2) | 0.73 | + | nuc | 0 | 600797 | 1338 | |||
Q8NHQ8 UniProt NPD GO | RASF8_HUMAN | Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1) | 0.73 | + | nuc | 0 | 608180 | 2CS4 | 419 | ||
O76094 UniProt NPD GO | SRP72_HUMAN | Signal recognition particle 72 kDa protein (SRP72) | 0.73 | + | nuc | 0 | Cytoplasm | 602122 | 670 | ||
Q92913 UniProt NPD GO | FGF13_HUMAN | Fibroblast growth factor 13 (FGF-13) (Fibroblast growth factor homologous factor 2) (FHF-2) | 0.72 | + | nuc | 0 | 300070 | 245 | |||
Q9P0M2 UniProt NPD GO | AKA7G_HUMAN | A-kinase anchor protein 7 isoform gamma (Protein kinase A-anchoring protein 7 isoform gamma) (A-kina ... | 0.71 | + | nuc | 0 | Cytoplasm | cytosol [IDA] | 604693 | 326 | |
Q14093 UniProt NPD GO | CYLC2_HUMAN | Cylicin-2 (Cylicin II) (Multiple-band polypeptide II) | 0.71 | + | nuc | 0 | Calyx. Sperm head cytoskeletal structure | 604035 | 348 | ||
Q9UH90 UniProt NPD GO | FBX40_HUMAN | F-box only protein 40 (Muscle disease-related protein) | 0.70 | + | nuc | 0 | 609107 | 709 | |||
P46821 UniProt NPD GO | MAP1B_HUMAN | Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1] | 0.70 | + | nuc | 0 | microtubule associated complex [TAS] | 157129 | 2468 | ||
O75317 UniProt NPD GO | UBP12_HUMAN | Ubiquitin carboxyl-terminal hydrolase 12 (EC 3.1.2.15) (Ubiquitin thioesterase 12) (Ubiquitin-specif ... | 0.70 | + | nuc | 0 | 603091 | 355 | |||
Q8TE56 UniProt NPD GO | ATS17_HUMAN | ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17 ... | 0.69 | + | nuc | 0 | Secreted protein; extracellular space; extracellular matrix (By similarity) | 607511 | 1095 | ||
P35611 UniProt NPD GO | ADDA_HUMAN | Alpha-adducin (Erythrocyte adducin subunit alpha) | 0.69 | + | nuc | 0 | 102680 | 737 | |||
O60927 UniProt NPD GO | PP1RB_HUMAN | Protein phosphatase 1 regulatory subunit 11 (Protein phosphatase inhibitor 3) (Hemochromatosis candi ... | 0.69 | + | nuc | 0 | soluble fraction [TAS] | 606670 | 126 | ||
Q99961 UniProt NPD GO | SH3G1_HUMAN | SH3-containing GRB2-like protein 1 (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion ge ... | 0.68 | + | nuc | 0 | Cytoplasm (By similarity). Membrane; peripheral membrane protein (By similarity). Associated with in ... | 601768 | 368 | ||
P17568 UniProt NPD GO | NDUB7_HUMAN | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquin ... | 0.67 | + | nuc | 0 | Mitochondrion; mitochondrial inner membrane; matrix side | 603842 | 136 | ||
P18124 UniProt NPD GO | RL7_HUMAN | 60S ribosomal protein L7 | 0.66 | + | nuc | 0 | cytosolic large ribosomal subunit (sensu Eu... [TAS] | 604166 | 248 | ||
O75052 UniProt NPD GO | CAPON_HUMAN | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of ne ... | 0.66 | + | nuc | 0 | cytoplasm [ISS] | 605551 | 506 | ||
P51878 UniProt NPD GO | CASP5_HUMAN | Caspase-5 precursor (EC 3.4.22.-) (CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III) [Contains: ... | 0.66 | + | nuc | 0 | 602665 | 418 | |||
Q13409 UniProt NPD GO | DC1I2_HUMAN | Cytoplasmic dynein 1 intermediate chain 2 (Dynein intermediate chain 2, cytosolic) (DH IC-2) (Cytopl ... | 0.66 | + | nuc | 0 | cytoplasm [NAS] | 603331 | 638 | ||
Q13153 UniProt NPD GO | PAK1_HUMAN | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alph ... | 0.65 | + | nuc | 0 | Cytoplasm. Cell membrane; cell-matrix junction; focal adhesion. Recruited to focal adhesions upon ac ... | 602590 | 1ZSG | 545 | |
P08476 UniProt NPD GO | INHBA_HUMAN | Inhibin beta A chain precursor (Activin beta-A chain) (Erythroid differentiation protein) (EDF) | 0.62 | + | nuc | 0 | Secreted protein | extracellular region [TAS] | 147290 | 2B0U | 426 |
P58753 UniProt NPD GO | TIRAP_HUMAN | Toll-interleukin 1 receptor domain-containing adapter protein (TIR domain-containing adapter protein ... | 0.62 | + | nuc | 0 | Cytoplasm (By similarity) | 606252 | 221 | ||
P36578 UniProt NPD GO | RL4_HUMAN | 60S ribosomal protein L4 (L1) | 0.61 | + | nuc | 0 | cytosolic large ribosomal subunit (sensu Eu... [TAS] | 180479 | 426 | ||
P57796 UniProt NPD GO | CABP4_HUMAN | Calcium-binding protein 4 (CaBP4) | 0.61 | + | nuc | 0 | Presynapses from both types of photoreceptors: rod spherules and cone pedicles (By similarity) | 608965 | 275 |
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If you find NucPred useful, please cite this paper:
NucPred - Predicting Nuclear Localization of Proteins. Brameier M, Krings A, Maccallum RM. Bioinformatics, 2007. PubMed id: 17332022The authors also look forward to your comments and suggestions. |
You have to decide on a NucPred score threshold. Sequences which score greater than or equal to this threshold are predicted to spend some time in the nucleus. Higher thresholds yield fewer predicted nuclear proteins, but these predictions are more accurate (you can have higher confidence in them). The table below gives more details of the performance of NucPred estimated using the sequences it was trained on (by cross-validation). Another benchmark is available in the Bioinformatics 2007 paper. |
NucPred score threshold | Specificity | Sensitivity |
see above | fraction of proteins predicted to be nuclear that actually are nuclear | fraction of true nuclear proteins that are predicted (coverage) |
0.10 | 0.45 | 0.88 |
0.20 | 0.52 | 0.83 |
0.30 | 0.57 | 0.77 |
0.40 | 0.63 | 0.69 |
0.50 | 0.70 | 0.62 |
0.60 | 0.71 | 0.53 |
0.70 | 0.81 | 0.44 |
0.80 | 0.84 | 0.32 |
0.90 | 0.88 | 0.21 |
1.00 | 1.00 | 0.02 |
Sequences which score >= 0.8 with NucPred and which are predicted by PredictNLS to contain an NLS have been shown to be 93% correct with a coverage of 16%. (PredictNLS by itself is 87% correct with 26% coverage on the same data.) |