NucPred on Proteomes

Authors: Andrea Krings, Amine Heddad, Markus Brameier and Bob MacCallum, Stockholm Bioinformatics Center, Stockholm University, Sweden.

NucPred - predictions for eukaryotic proteomes

Species:

Note: All filters/tests are combined with AND unless otherwise stated

Show only the proteins with links to database(s):
OMIM - human disease genes
PDB - protein 3D structure
( AND OR combination )

Annotation filters (can be slow! - Perl regexps allowed: e.g. nucleus|nucleolus)

UniProt ID (e.g. "PK3B_")
UniProt description (e.g. "kinase")
UniProt subcellular location
AND
UniProt GO component
AND
AND the
AND the

Only show proteins where the PredictNLS prediction is:

positive
negative

Only show proteins where the PSORT II predicted location

is is not

Click here: to filter by NucPred score

exclude all transmembrane proteins predicted by TMHMM
don't exclude lone N-terminal predicted transmembrane helices
(these could be signal peptides)

export all ACs and IDs as text file

Show proteins (ordered by NucPred score ) from to (currently 152 matches)

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UniProt accession	UniProt ID	UniProt description	NucPred score	Predict- NLS	PSORT II	TMHMM #helices	UniProt annotation for subcellular location	Uniprot GO cellular component	OMIM	PDB	sequence length
Q9NVP1 UniProt NPD GO	DDX18_HUMAN	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18) (Myc-regulated DEAD box protein) ...	0.90	+	nuc	0			606355		670
P11274 UniProt NPD GO	BCR_HUMAN	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen)	0.90	+	nuc	0			151410	1K1F	1271
Q96L91 UniProt NPD GO	EP400_HUMAN	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino ...	0.90	+	nuc	0			606265		3160
Q9UEY8 UniProt NPD GO	ADDG_HUMAN	Gamma-adducin (Adducin-like protein 70)	0.90	+	nuc	0		membrane [TAS]	601568		706
Q8N3R9 UniProt NPD GO	MPP5_HUMAN	MAGUK p55 subfamily member 5	0.90	+	nuc	0	Cell membrane; peripheral membrane protein. Intracellular membrane; peripheral membrane protein. Loc ...		606958	1Y76	675
Q99569 UniProt NPD GO	PKP4_HUMAN	Plakophilin-4 (p0071)	0.90	+	nuc	0	Cell membrane; cell-cell junction; desmosome. Colocalized with desmoplakin at desmosomal junctional ...	intercellular junction [TAS]	604276		1211
Q9NQ29 UniProt NPD GO	LUC7L_HUMAN	Putative RNA-binding protein Luc7-like 1 (SR+89) (Putative SR protein LUC7B1)	0.90	+	nuc	0			607782		371
Q96J92 UniProt NPD GO	WNK4_HUMAN	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase ...	0.90	+	nuc	0	Cell membrane; cell-cell junction; tight junction (By similarity). Present exclusively in intercellu ...	tight junction [ISS]	601844		1243
O00294 UniProt NPD GO	TULP1_HUMAN	Tubby-related protein 1 (Tubby-like protein 1)	0.90	+	nuc	0			600132	2FIM	542
Q7Z406 UniProt NPD GO	MYH14_HUMAN	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C)	0.89	+	nuc	0			608568		1995
P35579 UniProt NPD GO	MYH9_HUMAN	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC- ...	0.89	+	nuc	0			605249		1959
Q8N4C6 UniProt NPD GO	NIN_HUMAN	Ninein (hNinein)	0.89	+	nuc	0	Centrosome. Component of the core centrosome. Arranged in a tubular conformation with an open and a ...	centrosome [IDA]	608684		2090
Q6ZMN7 UniProt NPD GO	PZRN4_HUMAN	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein)	0.89	+	nuc	0			609730		1036
O75781 UniProt NPD GO	PALM_HUMAN	Paralemmin	0.89	+	nuc	0	Membrane; peripheral membrane protein (By similarity)	cytoplasmic membrane-bound vesicle [TAS] integral to plasma membrane [TAS] plasma membrane [NAS]	608134		387
Q14644 UniProt NPD GO	RASA3_HUMAN	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein)	0.89	+	nuc	0	Cell membrane	plasma membrane [TAS]	605182		834
Q9NR80 UniProt NPD GO	ARHG4_HUMAN	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef)	0.89	+	nuc	0	Isoform 3: Cytoplasm. Associated with membrane ruffles (Probable)		605216		657
Q96QB1 UniProt NPD GO	RHG07_HUMAN	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 pr ...	0.89	+	nuc	0	Cytoplasm (Potential)	cytoplasm [NAS]	604258		1091
Q9P0W8 UniProt NPD GO	SPAT7_HUMAN	Spermatogenesis-associated protein 7 (Spermatogenesis-associated protein HSD3) (HSD-3.1)	0.89	+	nuc	0			609868		599
O95872 UniProt NPD GO	BAT4_HUMAN	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein)	0.88	+	nuc	0			142610		356
Q7RTP6 UniProt NPD GO	MICA3_HUMAN	Protein MICAL-3	0.88	+	nuc	0	Cytoplasm (By similarity)		608882		976
P45379 UniProt NPD GO	TNNT2_HUMAN	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT)	0.88	+	nuc	0			115195	1J1E	297
Q15147 UniProt NPD GO	PLCB4_HUMAN	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide pho ...	0.87	+	nuc	0			600810		1175
P12259 UniProt NPD GO	FA5_HUMAN	Coagulation factor V precursor (Activated protein C cofactor) [Contains: Coagulation factor V heavy ...	0.87	+	nuc	0		extracellular region [NAS]	188055	1FV4	2224
P11387 UniProt NPD GO	TOP1_HUMAN	DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)	0.87	+	nuc	0			126420	1TL8	765
O60841 UniProt NPD GO	IF2P_HUMAN	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2)	0.87	+	nuc	0			606086		1220
Q99558 UniProt NPD GO	M3K14_HUMAN	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa beta-inducing kinase) (Se ...	0.87	+	nuc	0	Cytoplasm		604655		947
Q9UHJ3 UniProt NPD GO	SMBT1_HUMAN	Scm-like with four MBT domains protein 1 (Renal ubiquitous protein 1)	0.87	+	nuc	0			607319		866
Q8N103 UniProt NPD GO	TAGAP_HUMAN	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein)	0.87	+	nuc	0			609667		731
Q92558 UniProt NPD GO	WASF1_HUMAN	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Ve ...	0.87	+	nuc	0	Cytoplasm. Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas	actin cytoskeleton [TAS]	605035		559
Q07343 UniProt NPD GO	PDE4B_HUMAN	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32)	0.87	+	nuc	0		insoluble fraction [TAS] soluble fraction [TAS]	600127	2CHM	736
P84098 UniProt NPD GO	RL19_HUMAN	60S ribosomal protein L19	0.86	+	nuc	0			180466		196
P23508 UniProt NPD GO	CRCM_HUMAN	Colorectal mutant cancer protein (Protein MCC)	0.86	+	nuc	0			159350		829
P78563 UniProt NPD GO	RED1_HUMAN	Double-stranded RNA-specific editase 1 (EC 3.5.-.-) (dsRNA adenosine deaminase) (RNA-editing deamina ...	0.86	+	nuc	0			601218	1ZY7	741
Q9UPT5 UniProt NPD GO	EXOC7_HUMAN	Exocyst complex component 7 (Exocyst complex component Exo70)	0.86	+	nuc	0	Cytoplasm; cytosol (By similarity). Cell membrane; peripheral membrane protein (By similarity). Tran ...		608163		735
Q86UP2 UniProt NPD GO	KTN1_HUMAN	Kinectin (Kinesin receptor) (CG-1 antigen)	0.86	+	nuc	1 *	Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass type II membrane protein. Vesicle ...	endoplasmic reticulum membrane [ISS]	600381		1357
Q15149 UniProt NPD GO	PLEC1_HUMAN	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1)	0.86	+	nuc	0		plasma membrane [NAS]	131950	1MB8	4684
Q9NYF5 UniProt NPD GO	CE005_HUMAN	Protein C5orf5 (GAP-like protein N61)	0.86	+	nuc	0			609371		915
Q92997 UniProt NPD GO	DVL3_HUMAN	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3)	0.86	+	nuc	0	Cytoplasm (By similarity)		601368		716
Q8NE71 UniProt NPD GO	ABCF1_HUMAN	ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50) (TNF-alpha-stimulated ABC prote ...	0.85	+	nuc	0			603429		845
Q9UMZ2 UniProt NPD GO	SYNG_HUMAN	AP1 subunit gamma-binding protein 1 (Gamma-synergin)	0.84	+	nuc	0	Cytoplasm (By similarity). Golgi apparatus; trans-Golgi network; trans-Golgi network membrane; perip ...	AP-1 adaptor complex [TAS] cytoplasm [TAS] Golgi apparatus [TAS]	607291		1314
Q96SN8 UniProt NPD GO	CK5P2_HUMAN	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associ ...	0.84	+	nuc	0	Centrosome	centrosome [IDA] cytoskeleton [NAS]	608201		1893
Q08379 UniProt NPD GO	GOGA2_HUMAN	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95)	0.84	+	nuc	0	Golgi apparatus; Golgi stack; Golgi stack membrane; peripheral membrane protein	Golgi apparatus [IDA]	602580		990
Q969R2 UniProt NPD GO	OSBP2_HUMAN	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) ( ...	0.84	+	nuc	0	Membrane; peripheral membrane protein		606729		916
P78559 UniProt NPD GO	MAP1A_HUMAN	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light ...	0.82	+	nuc	0		microtubule associated complex [TAS]	600178		2805
Q92733 UniProt NPD GO	PRCC_HUMAN	Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein)	0.82	+	nuc	0			179755		491
P46940 UniProt NPD GO	IQGA1_HUMAN	Ras GTPase-activating-like protein IQGAP1 (p195)	0.82	+	nuc	0	Cell membrane	actin filament [TAS]	603379	1X0H	1657
O14640 UniProt NPD GO	DVL1_HUMAN	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)	0.82	+	nuc	0		cytoplasm [TAS]	601365		670
O95025 UniProt NPD GO	SEM3D_HUMAN	Semaphorin-3D precursor	0.82	+	nuc	1 *	Secreted protein (By similarity)		609907		777
P62241 UniProt NPD GO	RS8_HUMAN	40S ribosomal protein S8	0.81	+	nuc	0		cytosolic small ribosomal subunit (sensu Eu... [IDA]	600357		207
Q9UEE9 UniProt NPD GO	CFDP1_HUMAN	Craniofacial development protein 1 (Bucentaur)	0.81	+	nuc	0			608108		299
O96004 UniProt NPD GO	HAND1_HUMAN	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic ne ...	0.81	+	nuc	0			602406		215
O43491 UniProt NPD GO	E41L2_HUMAN	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G)	0.80	+	nuc	0		plasma membrane [TAS] spectrin [TAS]	603237		1005
P35612 UniProt NPD GO	ADDB_HUMAN	Beta-adducin (Erythrocyte adducin subunit beta)	0.80	+	nuc	0			102681		725
O00522 UniProt NPD GO	KRIT1_HUMAN	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 ...	0.80	+	nuc	0	Membrane; peripheral membrane protein (Probable)		604214		736
O43566 UniProt NPD GO	RGS14_HUMAN	Regulator of G-protein signaling 14 (RGS14)	0.80	+	nuc	0			602513		594
Q9Y6W5 UniProt NPD GO	WASF2_HUMAN	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Ve ...	0.80	+	nuc	0	Cytoplasm (By similarity). At the interface between the lamellipodial actin meshwork and the membran ...	actin cytoskeleton [TAS]	605875	2A40	498
P46779 UniProt NPD GO	RL28_HUMAN	60S ribosomal protein L28	0.79	+	nuc	0		cytosolic large ribosomal subunit (sensu Eu... [TAS]	603638		136
P12643 UniProt NPD GO	BMP2_HUMAN	Bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A)	0.79	+	nuc	1 *	Secreted protein		112261	3BMP	396
O75496 UniProt NPD GO	GEMI_HUMAN	Geminin	0.79	+	nuc	0			602842	1UII	209
P83731 UniProt NPD GO	RL24_HUMAN	60S ribosomal protein L24 (Ribosomal protein L30)	0.78	+	nuc	0			604180		157
P23352 UniProt NPD GO	KALM_HUMAN	Anosmin-1 precursor (Kallmann syndrome protein) (Adhesion molecule-like X-linked)	0.78	+	nuc	0	Cell surface	extracellular matrix (sensu Metazoa) [TAS] extracellular space [TAS]	308700	1ZLG	680
Q13202 UniProt NPD GO	DUS8_HUMAN	Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phospha ...	0.78	+	nuc	0		cytoplasm [TAS]	602038		625
Q9H3P7 UniProt NPD GO	GCP60_HUMAN	Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi phosphoprotein 1) ...	0.78	+	nuc	0	Golgi apparatus; Golgi membrane; peripheral membrane protein; cytoplasmic side (By similarity). Mito ...		606809		527
P48506 UniProt NPD GO	GSH1_HUMAN	Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (Gamma-glutamylcysteine synthetase) (Gamma ...	0.77	+	nuc	0			606857		636
Q14449 UniProt NPD GO	GRB14_HUMAN	Growth factor receptor-bound protein 14 (GRB14 adapter protein)	0.77	+	nuc	0	Cytoplasm. Golgi apparatus; Golgi membrane; peripheral membrane protein. Endosome; endosomal membran ...		601524	2AUH	540
Q9P2E9 UniProt NPD GO	RRBP1_HUMAN	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-r ...	0.77	+	nuc	1 *	Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass type III membrane protein (By sim ...	endoplasmic reticulum [NAS] integral to endoplasmic reticulum membrane [NAS] ribosome [TAS]	601418		1410
Q9Y5T5 UniProt NPD GO	UBP16_HUMAN	Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.1.2.15) (Ubiquitin thioesterase 16) (Ubiquitin-specif ...	0.77	+	nuc	0		cytoplasm [TAS]	604735		823
Q92574 UniProt NPD GO	TSC1_HUMAN	Hamartin (Tuberous sclerosis 1 protein)	0.76	+	nuc	0	Cytoplasm. Membrane; peripheral membrane protein. At steady state found in association with membrane ...		607341		1164
P11487 UniProt NPD GO	FGF3_HUMAN	INT-2 proto-oncogene protein precursor (Fibroblast growth factor 3) (FGF-3) (HBGF-3)	0.76	+	nuc	0		extracellular region [TAS]	164950		239
O14641 UniProt NPD GO	DVL2_HUMAN	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)	0.76	+	nuc	0	Cytoplasm	cytoplasm [TAS]	602151		736
Q14185 UniProt NPD GO	DOCK1_HUMAN	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)	0.75	+	nuc	0	Cytoplasm (Probable). Membrane (Probable). Recruited to membranes via its interaction with phosphati ...	cytoplasm [TAS]	601403		1865
Q02577 UniProt NPD GO	HEN2_HUMAN	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL-2)	0.75	+	nuc	0			162361		135
O00291 UniProt NPD GO	HIP1_HUMAN	Huntingtin-interacting protein 1 (HIP-I)	0.75	+	nuc	0	Intracytoplasmic membrane	cytoplasm [IDA] cytoskeleton [TAS] Golgi apparatus [IDA] membrane fraction [TAS]	601767		1030
Q13309 UniProt NPD GO	SKP2_HUMAN	S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (p45 ...	0.75	+	nuc	0			601436	2AST	424
Q14123 UniProt NPD GO	PDE1C_HUMAN	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) ...	0.74	+	nuc	0			602987	1LXS	709
P20042 UniProt NPD GO	IF2B_HUMAN	Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 sub ...	0.74	+	nuc	0		eukaryotic translation initiation factor 2 ... [TAS]	603908		333
Q9HCP0 UniProt NPD GO	KC1G1_HUMAN	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1)	0.73	+	nuc	0	Cytoplasm		606274	2CMW	422
Q9Y4H2 UniProt NPD GO	IRS2_HUMAN	Insulin receptor substrate 2 (IRS-2)	0.73	+	nuc	0			600797		1338
Q8NHQ8 UniProt NPD GO	RASF8_HUMAN	Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1)	0.73	+	nuc	0			608180	2CS4	419
O76094 UniProt NPD GO	SRP72_HUMAN	Signal recognition particle 72 kDa protein (SRP72)	0.73	+	nuc	0	Cytoplasm		602122		670
Q92913 UniProt NPD GO	FGF13_HUMAN	Fibroblast growth factor 13 (FGF-13) (Fibroblast growth factor homologous factor 2) (FHF-2)	0.72	+	nuc	0			300070		245
Q9P0M2 UniProt NPD GO	AKA7G_HUMAN	A-kinase anchor protein 7 isoform gamma (Protein kinase A-anchoring protein 7 isoform gamma) (A-kina ...	0.71	+	nuc	0	Cytoplasm	cytosol [IDA]	604693		326
Q14093 UniProt NPD GO	CYLC2_HUMAN	Cylicin-2 (Cylicin II) (Multiple-band polypeptide II)	0.71	+	nuc	0	Calyx. Sperm head cytoskeletal structure		604035		348
Q9UH90 UniProt NPD GO	FBX40_HUMAN	F-box only protein 40 (Muscle disease-related protein)	0.70	+	nuc	0			609107		709
P46821 UniProt NPD GO	MAP1B_HUMAN	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1]	0.70	+	nuc	0		microtubule associated complex [TAS]	157129		2468
O75317 UniProt NPD GO	UBP12_HUMAN	Ubiquitin carboxyl-terminal hydrolase 12 (EC 3.1.2.15) (Ubiquitin thioesterase 12) (Ubiquitin-specif ...	0.70	+	nuc	0			603091		355
Q8TE56 UniProt NPD GO	ATS17_HUMAN	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17 ...	0.69	+	nuc	0	Secreted protein; extracellular space; extracellular matrix (By similarity)		607511		1095
P35611 UniProt NPD GO	ADDA_HUMAN	Alpha-adducin (Erythrocyte adducin subunit alpha)	0.69	+	nuc	0			102680		737
O60927 UniProt NPD GO	PP1RB_HUMAN	Protein phosphatase 1 regulatory subunit 11 (Protein phosphatase inhibitor 3) (Hemochromatosis candi ...	0.69	+	nuc	0		soluble fraction [TAS]	606670		126
Q99961 UniProt NPD GO	SH3G1_HUMAN	SH3-containing GRB2-like protein 1 (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion ge ...	0.68	+	nuc	0	Cytoplasm (By similarity). Membrane; peripheral membrane protein (By similarity). Associated with in ...		601768		368
P17568 UniProt NPD GO	NDUB7_HUMAN	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquin ...	0.67	+	nuc	0	Mitochondrion; mitochondrial inner membrane; matrix side		603842		136
P18124 UniProt NPD GO	RL7_HUMAN	60S ribosomal protein L7	0.66	+	nuc	0		cytosolic large ribosomal subunit (sensu Eu... [TAS]	604166		248
O75052 UniProt NPD GO	CAPON_HUMAN	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of ne ...	0.66	+	nuc	0		cytoplasm [ISS]	605551		506
P51878 UniProt NPD GO	CASP5_HUMAN	Caspase-5 precursor (EC 3.4.22.-) (CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III) [Contains: ...	0.66	+	nuc	0			602665		418
Q13409 UniProt NPD GO	DC1I2_HUMAN	Cytoplasmic dynein 1 intermediate chain 2 (Dynein intermediate chain 2, cytosolic) (DH IC-2) (Cytopl ...	0.66	+	nuc	0		cytoplasm [NAS]	603331		638
Q13153 UniProt NPD GO	PAK1_HUMAN	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alph ...	0.65	+	nuc	0	Cytoplasm. Cell membrane; cell-matrix junction; focal adhesion. Recruited to focal adhesions upon ac ...		602590	1ZSG	545
P08476 UniProt NPD GO	INHBA_HUMAN	Inhibin beta A chain precursor (Activin beta-A chain) (Erythroid differentiation protein) (EDF)	0.62	+	nuc	0	Secreted protein	extracellular region [TAS]	147290	2B0U	426
P58753 UniProt NPD GO	TIRAP_HUMAN	Toll-interleukin 1 receptor domain-containing adapter protein (TIR domain-containing adapter protein ...	0.62	+	nuc	0	Cytoplasm (By similarity)		606252		221
P36578 UniProt NPD GO	RL4_HUMAN	60S ribosomal protein L4 (L1)	0.61	+	nuc	0		cytosolic large ribosomal subunit (sensu Eu... [TAS]	180479		426
P57796 UniProt NPD GO	CABP4_HUMAN	Calcium-binding protein 4 (CaBP4)	0.61	+	nuc	0	Presynapses from both types of photoreceptors: rod spherules and cone pedicles (By similarity)		608965		275

You are viewing entries 1 to 100 of 152. You can see more proteins by changing the limits in the form at the top of this page, or click here for the next page of proteins .

If you find NucPred useful, please cite this paper:

NucPred - Predicting Nuclear Localization of Proteins. Brameier M, Krings A, Maccallum RM. Bioinformatics, 2007. PubMed id: 17332022

The authors also look forward to your comments and suggestions.

What does the NucPred score mean?

You have to decide on a NucPred score threshold. Sequences which score greater than or equal to this threshold are predicted to spend some time in the nucleus. Higher thresholds yield fewer predicted nuclear proteins, but these predictions are more accurate (you can have higher confidence in them). The table below gives more details of the performance of NucPred estimated using the sequences it was trained on (by cross-validation). Another benchmark is available in the Bioinformatics 2007 paper.

NucPred score threshold	Specificity	Sensitivity
see above	fraction of proteins predicted to be nuclear that actually are nuclear	fraction of true nuclear proteins that are predicted (coverage)
0.10	0.45	0.88
0.20	0.52	0.83
0.30	0.57	0.77
0.40	0.63	0.69
0.50	0.70	0.62
0.60	0.71	0.53
0.70	0.81	0.44
0.80	0.84	0.32
0.90	0.88	0.21
1.00	1.00	0.02

Sequences which score >= 0.8 with NucPred and which are predicted by PredictNLS to contain an NLS have been shown to be 93% correct with a coverage of 16%. (PredictNLS by itself is 87% correct with 26% coverage on the same data.)

Go back to the NucPred Home Page.