![]() | Authors: Andrea Krings, Amine Heddad, Markus Brameier and Bob MacCallum, Stockholm Bioinformatics Center, Stockholm University, Sweden. |
UniProt accession | UniProt ID | UniProt description | NucPred score | Predict- NLS | PSORT II | TMHMM #helices | UniProt annotation for subcellular location | Uniprot GO cellular component | OMIM | PDB | sequence length |
P62285 UniProt NPD GO | ASPM_BOVIN | Abnormal spindle-like microcephaly-associated protein homolog (Fragment) | 0.92 | - | nuc | 0 | Cytoplasm (By similarity). Nucleus (By similarity). The nuclear-cytoplasmic distribution could be re ... | 3371 | |||
Q01631 UniProt NPD GO | CYAA_NEUCR | Adenylate cyclase (EC 4.6.1.1) (ATP pyrophosphate-lyase) (Adenylyl cyclase) | 0.92 | - | nuc | 0 | 2300 | ||||
P49606 UniProt NPD GO | CYAA_USTMA | Adenylate cyclase (EC 4.6.1.1) (ATP pyrophosphate-lyase) (Adenylyl cyclase) | 0.92 | - | nuc | 0 | 2493 | ||||
Q4P6G5 UniProt NPD GO | SPB1_USTMA | AdoMet-dependent rRNA methyltransferase SPB1 (EC 2.1.1.-) (2'-O-ribose RNA methyltransferase) (S-ade ... | 0.92 | - | nuc | 0 | Nucleus; nucleolus (By similarity) | 921 | |||
Q4WVH3 UniProt NPD GO | SPB1_ASPFU | AdoMet-dependent rRNA methyltransferase spb1 (EC 2.1.1.-) (2'-O-ribose RNA methyltransferase) (S-ade ... | 0.92 | + | nuc | 0 | Nucleus; nucleolus (By similarity) | 795 | |||
Q61329 UniProt NPD GO | ATBF1_MOUSE | Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription facto ... | 0.92 | - | nuc | 0 | Nucleus | mitochondrion [IDA] nucleus [NAS] | 3726 | ||
Q8N6M6 UniProt NPD GO | AMPO_HUMAN | Aminopeptidase O (EC 3.4.11.-) (AP-O) | 0.92 | + | cyt | 0 | Cytoplasm (Potential) | 819 | |||
Q811D2 UniProt NPD GO | ANR26_MOUSE | Ankyrin repeat domain-containing protein 26 | 0.92 | - | nuc | 0 | 1581 | ||||
P79832 UniProt NPD GO | ARNT_ONCMY | Aryl hydrocarbon receptor nuclear translocator (rtARNT) | 0.92 | + | nuc | 0 | Nucleus | 723 | |||
P54254 UniProt NPD GO | ATX1_MOUSE | Ataxin-1 (Spinocerebellar ataxia type 1 protein homolog) | 0.92 | + | nuc | 0 | Cytoplasm. Nucleus | nuclear inclusion body [IDA] | 792 | ||
Q51UJ9 UniProt NPD GO | ATG11_MAGGR | Autophagy-related protein 11 | 0.92 | - | nuc | 0 | Vacuole; vacuolar membrane; peripheral membrane protein (By similarity). Vacuolar and perivacuolar p ... | 1407 | |||
P12957 UniProt NPD GO | CALD1_CHICK | Caldesmon (CDM) | 0.92 | + | nuc | 0 | On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle) (By similarity) | 771 | |||
O94983 UniProt NPD GO | CMTA2_HUMAN | Calmodulin-binding transcription activator 2 | 0.92 | + | nuc | 0 | Nucleus (Probable) | 1202 | |||
Q80Y50 UniProt NPD GO | CMTA2_MOUSE | Calmodulin-binding transcription activator 2 | 0.92 | + | nuc | 0 | Nucleus (Probable) | 1208 | |||
P56369 UniProt NPD GO | FTSH_CHLVU | Cell division protein ftsH homolog | 0.92 | - | nuc | 0 | Plastid; chloroplast; chloroplast membrane; multi-pass membrane protein (Potential) | 1720 | |||
P49454 UniProt NPD GO | CENPF_HUMAN | Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen) | 0.92 | + | nuc | 0 | Nucleus; nucleoplasm; nuclear matrix. But not in the nucleolus, reorganization to the kinetochore/ce ... | cytoplasm [IDA] kinetochore [IDA] nuclear envelope [IDA] nuclear matrix [IDA] nucleus [IDA] outer kinetochore of condensed chromosome [IDA] spindle pole [IDA] | 600236 | 3210 | |
Q9BV73 UniProt NPD GO | CP250_HUMAN | Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) ... | 0.92 | - | nuc | 0 | Cytoplasm; perinuclear region. Centrosome. Component of the core centrosome. In interphase cells, it ... | centrosome [IDA] | 609689 | 2442 | |
Q9DB85 UniProt NPD GO | HUCE1_MOUSE | Cerebral protein 1 homolog | 0.92 | + | nuc | 0 | Nucleus; nucleolus (By similarity) | 457 | |||
P32641 UniProt NPD GO | RAD24_YEAST | Checkpoint protein RAD24 | 0.92 | - | mit | 0 | Nucleus (Potential) | DNA replication factor C complex [TAS] nucleus [IPI] | 659 | ||
P50531 UniProt NPD GO | RAD17_SCHPO | Checkpoint protein rad17 | 0.92 | + | nuc | 0 | Nucleus | Rad17 RFC-like complex [TAS] | 606 | ||
O00409 UniProt NPD GO | FOXN3_HUMAN | Checkpoint suppressor 1 (Forkhead box protein N3) | 0.92 | + | nuc | 0 | Nucleus (Probable) | nucleus [IC] | 602628 | 490 | |
Q499D0 UniProt NPD GO | FOXN3_MOUSE | Checkpoint suppressor 1 (Forkhead box protein N3) | 0.92 | + | nuc | 0 | Nucleus (Probable) | nucleus [RCA] | 457 | ||
Q4P209 UniProt NPD GO | VID21_USTMA | Chromatin modification-related protein VID21 | 0.92 | - | nuc | 0 | Nucleus (Probable) | 1654 | |||
Q757W2 UniProt NPD GO | YNG2_ASHGO | Chromatin modification-related protein YNG2 (ING1 homolog 2) | 0.92 | - | nuc | 0 | Nucleus (By similarity) | 285 | |||
Q8TDI0 UniProt NPD GO | CHD5_HUMAN | Chromodomain helicase-DNA-binding protein 5 (EC 3.6.1.-) (ATP-dependent helicase CHD5) (CHD-5) | 0.92 | + | nuc | 0 | Nucleus (By similarity) | 1954 | |||
O61735 UniProt NPD GO | CLOCK_DROME | Circadian locomoter output cycles protein kaput (dCLOCK) (dPAS1) | 0.92 | + | nuc | 0 | Nucleus (Potential) | nucleus [NAS] | 1027 | ||
O18806 UniProt NPD GO | FA8_CANFA | Coagulation factor VIII precursor (Procoagulant component) | 0.92 | - | nuc | 0 | Secreted protein; extracellular space (By similarity) | 2343 | |||
Q9D3E6 UniProt NPD GO | STAG1_MOUSE | Cohesin subunit SA-1 (Stromal antigen 1) (SCC3 homolog 1) | 0.92 | - | nuc | 0 | Nucleus (By similarity). Associates with chromatin. Before prophase it is scattered along chromosome ... | 1258 | |||
O35638 UniProt NPD GO | STAG2_MOUSE | Cohesin subunit SA-2 (Stromal antigen 2) (SCC3 homolog 2) | 0.92 | - | nuc | 0 | Nucleus. Associates with chromatin. Before prophase it is scattered along chromosome arms. During pr ... | 1231 | |||
Q5PR68 UniProt NPD GO | CCD46_MOUSE | Coiled coil domain-containing protein 46 | 0.92 | - | nuc | 0 | 954 | ||||
Q8K2I2 UniProt NPD GO | CCHCR_MOUSE | Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein) | 0.92 | - | nuc | 0 | Cytoplasm (By similarity). Nucleus (By similarity) | cytoplasm [IDA] | 770 | ||
Q8CDN8 UniProt NPD GO | CCD38_MOUSE | Coiled-coil domain-containing protein 38 | 0.92 | - | nuc | 0 | 563 | ||||
Q9UFE4 UniProt NPD GO | CCD39_HUMAN | Coiled-coil domain-containing protein 39 | 0.92 | - | nuc | 0 | 755 | ||||
Q9Y592 UniProt NPD GO | CCD41_HUMAN | Coiled-coil domain-containing protein 41 (NY-REN-58 antigen) | 0.92 | - | nuc | 0 | 693 | ||||
Q568R1 UniProt NPD GO | CCD55_BRARE | Coiled-coil domain-containing protein 55 | 0.92 | - | nuc | 0 | 516 | ||||
Q04149 UniProt NPD GO | MUS81_YEAST | Crossover junction endonuclease MUS81 (EC 3.1.22.-) (MMS and UV sensitive protein 81) | 0.92 | - | nuc | 0 | Nucleus | nucleus [IMP] | 632 | ||
O43889 UniProt NPD GO | CREB3_HUMAN | Cyclic AMP-responsive element-binding protein 3 (Luman protein) (Transcription factor LZIP-alpha) | 0.92 | + | nuc | 0 | Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass type II membrane protein. Process ... | 606443 | 395 | ||
Q6GN15 UniProt NPD GO | CCNL1_XENLA | Cyclin-L1 | 0.92 | + | nuc | 0 | Nucleus (By similarity) | 496 | |||
P35662 UniProt NPD GO | CYLC1_BOVIN | Cylicin-1 (Cylicin I) (Multiple-band polypeptide I) | 0.92 | + | nuc | 0 | Calyx. Sperm head cytoskeletal structure | 667 | |||
Q6E3D4 UniProt NPD GO | CPB3_CAERE | Cytoplasmic polyadenylation element-binding protein 3 | 0.92 | - | nuc | 0 | 766 | ||||
O75140 UniProt NPD GO | DEPD5_HUMAN | DEP domain-containing protein 5 | 0.92 | - | nuc | 0 | 1572 | ||||
P61460 UniProt NPD GO | DEPD5_MOUSE | DEP domain-containing protein 5 | 0.92 | - | nuc | 0 | 1527 | ||||
O74502 UniProt NPD GO | MSH6_SCHPO | DNA mismatch repair protein msh6 | 0.92 | - | nuc | 0 | Nucleus (Probable) | 1254 | |||
O00874 UniProt NPD GO | DPOLA_LEIDO | DNA polymerase alpha catalytic subunit (EC 2.7.7.7) | 0.92 | + | mit | 0 | Nucleus | 1339 | |||
Q27152 UniProt NPD GO | DPOLA_OXYTR | DNA polymerase alpha catalytic subunit (EC 2.7.7.7) | 0.92 | + | nuc | 0 | Nucleus | 1513 | |||
Q6FNY7 UniProt NPD GO | DPOE_CANGA | DNA polymerase epsilon, catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A) | 0.92 | - | nuc | 0 | Nucleus (By similarity) | 2217 | |||
Q6CUS7 UniProt NPD GO | DPOE_KLULA | DNA polymerase epsilon, catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A) | 0.92 | + | nuc | 0 | Nucleus (By similarity) | 2185 | |||
Q9UBT6 UniProt NPD GO | POLK_HUMAN | DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP) | 0.92 | - | nuc | 0 | Nucleus. Detected throughout the nucleus and at replication foci | 605650 | 1T94 | 870 | |
P38121 UniProt NPD GO | DPOA2_YEAST | DNA polymerase subunit alpha B (DNA polymerase I subunit B) (DNA polymerase alpha:primase complex p8 ... | 0.92 | + | nuc | 0 | Nucleus | alpha DNA polymerase:primase complex [TAS] nuclear envelope [IDA] nucleus [IDA] | 705 | ||
Q4IJ84 UniProt NPD GO | RAD5_GIBZE | DNA repair protein RAD5 (EC 3.6.1.-) | 0.92 | - | nuc | 0 | Cytoplasm (By similarity). Nucleus (By similarity) | 1154 |
You are viewing entries 3151 to 3200 of 98716. You can see more proteins by changing the limits in the form at the top of this page, or click here for the next page of proteins .
If you find NucPred useful, please cite this paper:
NucPred - Predicting Nuclear Localization of Proteins. Brameier M, Krings A, Maccallum RM. Bioinformatics, 2007. PubMed id: 17332022The authors also look forward to your comments and suggestions. |
You have to decide on a NucPred score threshold. Sequences which score greater than or equal to this threshold are predicted to spend some time in the nucleus. Higher thresholds yield fewer predicted nuclear proteins, but these predictions are more accurate (you can have higher confidence in them). The table below gives more details of the performance of NucPred estimated using the sequences it was trained on (by cross-validation). Another benchmark is available in the Bioinformatics 2007 paper. |
NucPred score threshold | Specificity | Sensitivity |
see above | fraction of proteins predicted to be nuclear that actually are nuclear | fraction of true nuclear proteins that are predicted (coverage) |
0.10 | 0.45 | 0.88 |
0.20 | 0.52 | 0.83 |
0.30 | 0.57 | 0.77 |
0.40 | 0.63 | 0.69 |
0.50 | 0.70 | 0.62 |
0.60 | 0.71 | 0.53 |
0.70 | 0.81 | 0.44 |
0.80 | 0.84 | 0.32 |
0.90 | 0.88 | 0.21 |
1.00 | 1.00 | 0.02 |
Sequences which score >= 0.8 with NucPred and which are predicted by PredictNLS to contain an NLS have been shown to be 93% correct with a coverage of 16%. (PredictNLS by itself is 87% correct with 26% coverage on the same data.) |